The fields of cellular medicine, regenerative and stem cell therapies continue to grow exponentially, particularly as it relates to therapeutics and diagnostics. Early cutaneous applications of cellular medicine saw success with human dermal-derived, tissue cultured, autologous injectable fibroblasts. The next advancement in autologous regenerative therapy surrounded Stromal Vascular Fraction (SVF) procured from adipose tissue lipoaspirate via a near closed specialized sterile surgical processing system
Few studies have examined the therapeutic benefits of MSC EV’s in treating aging skin and the many problems associated with aging such as loss of elasticity reduced collagen synthesis and function pigmentary changes and dysplasia leading to cutaneous carcinomas. MSC exosomes have several therapeutic effects on skin.
They are able to stimulate fibroblast proliferation and migration, increase collagen extracellular matrix production and deposition, promote angiogenesis in acute and chronic woods, modulate inflammation and the immune response and regulate tissue remodeling to reduce adverse scarring.
In conclusion, human placental mesenchymal stem cell-derived exosomes are a valuable addition to the armamentarium of the physician treating aging skin and associated dermatopathology.